I like the new signage, but I think that the RT routes should include a letter prefix indicating the type of service (S = subway, L = LRT, B = BRT, E = GO REX, R = Regional GO rail). That way, the naming convention can be applied across the entire region, and eventually routes in the 905 can be added using the same standard.
The other thing I'd like to see is odd numbered routes being N-S routes, and even numbered routes being E-W routes. That may result in some of the numbering sequence being a tad out of order (more E-W routes than N-S routes), but it would make wayfinding a lot easier, knowing that, just based on the number, you can tell which on which axis you're travelling.