Skeezix
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It's not hard to thrive when you're located on a major pedestrian thoroughfare through downtown. Those businesses essentially have a captive market.
Not really a captive market. There are a lot of food and retail options off Yonge (or under Yonge when one considers the PATH), particularly south of Gerrard and then again towards Bloor. Noncompetitive/unappealing businesses can, and do, go belly up because people have choices, and are for the most part not even tied to Yonge.
There are a number of pedestrian friendly thoroughfares in the central city where businesses struggle and/or are largely marginal. A busy streets with retail spaces along the sidewalk is not necessarily in and of itself a recipe for success.