HSR itself may well go to Pearson, and the Kitchener Line would still go to Union.
Unlike a high speed rail line, a rapid transit line can intercept transit lines at a variety of different locations across the city. On an HSR line, we'd want to keep the stations to a minimum to maintain the high average speeds, so it's much more critical to stop at a couple locations with a lot of different connections.
The Ontario Line would intercept most of the lines heading downtown:
LSW at Exhibition
Line 2 at Dundas West, possibly Milton line
Kitchener Line at Dundas West, Mount Dennis and Woodbine Racetrack
Line 5 at Mount Dennis
Bolton Line at Mount Dennis
Line 1 University at Osgoode
Line 1 Yonge at Queen
Stouffville Line & LSE at East Harbour
Line 2 at Pape
Line 5 at Don Mills & Eglinton