Saying that "mutation is natural" is an empty statement. Mutation is simply a fundamental biololgical mechanism which creates/sustains genetic diversity.
More relevant would be its effect on fitness: neutral, positive, or negative. It would also be important to look at how our environment is affecting the frequency of these mutations. Cancer IS natural, but its frequency may not be.
The "it's natural" argument is not a good one, which is why I cringe when it's used in support of homosexuality. Unethical behaviours are completely natural (ie. adultery, murder, and shitting on the spot your standing on).
Poverty should be examined in terms of its role in a capitalist system. IMO, dire poverty is not a cog in the machine, but people making min-wage IS a huge cog in the machine.
Ok, sorry to take this off-topic.