So, I will try to make my response as value neutral as possible: I don't have a problem with 20 year-olds from the 905 driving into town to get drunk, mac on girls and puke in the streets. It's sort of a rite of passage for that age group and most people get it out of their system by the time they're 25. As ridiculous and plastic as the scene might seem, some people revel in it and it's good for them to have a place to let loose.
I do have a problem with all of this sort of activity being concentrated into one area, allowing this kind of behaviour to amplify out of proportion. If clubgoers have a "right to the city", so do the other city dwellers. On Friday and Saturday nights "clubland" basically becomes a no-go zone for anyone who is under 30 or passing through alone. I mean, there is no neighbourhood in Toronto that I would have second thoughts walking through late at night alone, but I used to make a significant detour if I needed to get to the other side of clubland at 2 in the morning. When roving groups of horny young men and drunken girls with a propensity for yelling suddenly become the vast majority of the people on a sidewalk, walking around Richmond, Adelaide and Duncan by yourself is downright unpleasant. If their presence was diluted by other late night venturers, particularly those that don't have a pretext of hunting for pussy in packs: couples on dates, art gallery goers, shoppers filtering out of late night stores, diners leaving restaurants, etc. It would be in the interest of the majority if many of the clubs shut down and were dispersed across the city.