To be fair, colleges are huge trip generators. I'm at Mohawk now, and the number of students taking transit to school in the past few years has increased significantly. The proposed A-Line LRT route even has the line making a short jog off of James to serve the college, and then jumping back onto James south of it. Mohawk is also building an integrated transit station on the southwest corner of Fennell & West 5th, in order to increase efficiency and consolidate multiple stops in and around the campus into one centralized stop. There's no reason a HMLRT option that runs along Steeles couldn't route into an integrated transit loop at Sheridan.
Of all the anti-Main reasons that were presented last night (many of which are total BS), that one actually does have some merit to it. Serving college and university campuses with rapid transit has been a key factor in many other projects across the GTHA: Centennial College with the SLRT, UTSC with Durham Pulse, York U with the TYSSE, Humber with the FWLRT, McMaster with the B-Line LRT, Mohawk with the A-Line LRT. A few of those lines mentioned even terminate (or should terminate) at those campuses. I can't think of a single instance where a proposed RT line runs within a couple km of a major campus and doesn't directly serve it.