Predicting out to 2050 is a bit of a mug's game. At that timespan demand is largely a function of zoning. Why the City would concentrate all of its development along Yonge while the Spadina and BD lines are under capacity is a mystery to me. It would be way simpler to funnel development elsewhere than building a 'second Yonge line.'
In the DRTES 2031 peak demand, even with a Yonge extension and no DRL, was under 40k pph/pd. With planned upgrades that's slightly overcapacity, though relatively less so that we currently are. Further measures like a 7th train and fold-up seats would give that some cushioning. Obviously not ideal but hardly justifying twinning the line.
I would say our current network is... less than ideal in that our main EW line (BD) more or less misses downtown, forcing riders to transfer south bound onto Yonge. A DRL, in just about any fashion, would fix a lot of that.
Just to be explicit, if Toronto ever has to twin the Yonge line it will be a MASSIVE failure of planning. There is enough open space in this City that we don't have to resort to that. I don't actually know of any City which has had to do this, even those with populations 10x Toronto's...