Science Centre Station will be an underground station and Mobility Hub, located at the intersection of Don Mills Road and Eglinton Avenue East. The station will include an off-street TTC Bus Terminal.

There will be two fully accessible entrances – the main at the southwest corner of Eglinton Avenue and Don Mills Road, and the secondary entrance, incorporated into the bus terminal on the northeast corner of Eglinton and Don Mills Road.

The bus terminal will include seven bus bays for TTC buses, with on-street bus connections. There will also be an underground, accessible connection to the LRT concourse level, along with retail spaces at this level.

There will be 30 outdoor and 30 indoor bicycle parking spaces.